A Polyvinyl Chloride Plastisol (PVCp) based optofluidic Lab-on-a-chip Device to Mimic the Optical and Accoustic Properties of Vascularized Human Tissue

Conclusions: During the research work, the PVCp material was chosen to be the matrix material of the optofluidic chip due to its intrinsic characteristics such as insoluble in water and stable for a long time. Although it also forms the albinism when immersing in water, this phenomenon can be healed in 3 hours. An optofluidic chip composed of PVCp sub- and superstrate with the defined thickness and a hollow microfluidic structure embedded is able to achieve the similar morphology characteristics of tissues especially the human cutis including the two layered and the microvasculature structure. With the application of the SIMDOS diaphragm pump assigned and the SDOCT imaging, the vasculature geometry and micro-circulation of the fabricated chip are reconstructed properly as well as the lamination between layers are also investigated.

To achieve the similar optical properties of human cutaneous tissues, different amounts of Titanium Oxide powder and ink was inserted in the PVCp matrix and tune their absorption coefficient μα and reduced scattering coefficient μς which cover the properties of tissues mostly in the visible and infrared region.

Moreover, by inserting different concentrations of the softener in the PVCp matrix, its similar Young's modules E and the acoustic velocity with that of soft tissues was almost achieved and the results here indicate that the experimental values of Young's modulus almost match with that of soft tissue and the tendency of acoustic speed variated with the softener concentration can validate its dependency on the mechanical elasticity.