Friedrich-Alexander-Universität Erlangen-Nürnberg

Visual Pathway Analysis in Glaucoma using Diffusion Tensor Imaging

Visual Pathway Analysis in Glaucoma using Diffusion Tensor Imaging

Millions of people in the world suffer from glaucoma, the second leading cause of vision loss in the world. Fewer than 50% of people with glaucoma are aware of their disease. The blindness caused by glaucoma is irreversible. Therefore, improved methods of screening and therapy for glaucoma are urgently needed. Different imaging modalities exist for acquiring images of the eye. Most of these modalities focus on imaging the retina, but the human visual system does not only consist of the eye but it is extended into the brain through the optic nerve till the visual cortex.

Diffusion tensor imaging is based on diffusion weighted magnetic resonance imaging where the Brownian motion of water molecules is used to modulate the magnetic resonance signals. Therefore, diffusion weighted images can be used to probe the structure of the brain. The diffusion tensor imaging modality is the only modality that allows tracking the white matter fibers in the brain non-invasively. The figure below shows a color-coded fractional anisotropy image, that represents the diffusion tensor data in a brain slice. The aim of this work is to identify the visual system on diffusion tensor images and analyze the abnormalities in it due to glaucoma. This facilitates the understanding of the pathophysiology of glaucoma and opens new dimensions in the diagnosis of glaucoma.

Publications:

 

A. El-Rafei, J. Hornegger, T. Engelhorn, A. Dörfler, S. Wärntges, G. Michelson, “Automatic Segmentation of the Optic Radiation Using DTI in Glaucoma Patients”. Proceeding of the 2009 II ECCOMAS Thematic Conference on Computational Vision and Medical Image Processing (VipIMAGE), Porto, Portugal, 14-16 October 2009. Taylor and Francis, 2009, p. 293-298.

El-Rafei, T. Engelhorn, S. Wärntges, A. Dörfler, J. Hornegger, and G. Michelson, “Automatic Segmentation of the Optic Radiation Using DTI in Healthy Subjects and Patients with Glaucoma”. Computational Vision and Medical Image Processing - Recent Trends. Series: “Computational Methods in Applied Sciences”, Vol. 19 by Springer. Pages: 1-15. 2011.

Ahmed El-Rafei, Tobias Engelhorn, Simone Wärntges, Arnd Dörfler, Joachim Hornegger, Georg Michelson, A framework for voxel-based morphometric analysis of the optic radiation using diffusion tensor imaging in glaucoma, Magnetic Resonance Imaging, Volume 29, Issue 8, October 2011, Pages 1076-1087.

A. El-Rafei, T. Engelhorn, S. Wärntges, A. Dörfler, J. Hornegger, G. Michelson, “Glaucoma Classification Based on Histogram Analysis of Diffusion Tensor Imaging Measures in the Optic Radiation”. Lecture Notes in Computer Science - Computer Analysis of Images and Patterns 2011, Volume 6854, pp. 529-536.

 

Mission

SAOT provides an interdisciplinary research and education program of excellence within a broad international network of distinguished experts to promote innovation and leadership in the areas

Optical Metrology
Optical Material Processing
Optics in Medicine
Optics in Communication and Information Technology
Optical Materials and Systems
and Computational Optics.