Friedrich-Alexander-Universität Erlangen-Nürnberg

Advanced Fundus Imaging for Early Detection of Eye Diseases

Advanced Fundus Imaging for Early Detection of Eye Diseases

New optical scanning techniques like optical coherent tomography (OCT) allow high resolution imaging of the depth structure of the retina. The goal of the project is to improve the ability for early detection of eye diseases and to diagnose their progress based on this new imaging techniques. The focus lies on glaucoma diseases. Methods that provide ophthalmologists new possibilities to judge image data should be developed. An example for such a method is an automated segmentation and thickness measurement of the nerve fiber layer. Furthermore, the outcomings of the image processing must be visualised in an appropriate manner. The ophthalmologic department brings in its experience in the development and application of new methods in ophthalmology, particularly from the SFB 539. Together with the competence of the institute for pattern recognition in medical image processing this is an excellent base for the project.



Illustration 1: Segmentation result and retinal nerve viber layer thickness visualization generated with OCTSEG



  • Automated Retinal Layer Segmentation
  • OCT Image Denoising
  • Automated Glaucoma Classification using OCT Images
  • OCTSEG (Optical Coherence Tomography Segmentation and Evaluation  Graphical User Interface)



Project partners:

Ophthalmology (Dr. Ralf Tornow, Prof. Christian Mardin, Prof. Dr. med Friedrich E. Kruse) and Institute for Pattern Recognition (Dipl.-Inf. Markus Mayer, Prof. Dr.-Ing. Joachim Hornegger), University of Erlangen-Nuremberg


Journal Articles:

„Retinal Nerve Fiber Layer Segmentation on FD-OCT Scans of Normal Subjects and Glaucoma Patients“. Mayer, Markus; Hornegger, Joachim; Mardin, Christian Y.; Tornow, Ralf-Peter.
In: Biomedical Optics Express 1 (2010) No. 5 pp. 1358-1383


„Atypical Retardation Patterns in Scanning Laser Polarimetry are associated with low Peripapillary Choroidal Thickness“. Ralf P. Tornow, Wolfgang A. Schrems, Delia Bendschneider, Folkert K. Horn, Markus Mayer, Christian Y. Mardin, and Robert Lämmer.
In: Invest. Ophthalmol. Vis. Sci. published 23 August 2011, 10.1167/iovs.11-7557


Conference Proceeding:

The Association for Research in Vision and Ophthalmology, Inc. (ARVO), Annual Meeting, Fort Lauderdale, USA: 2008, 2009, 2010, 2011

Biosignal 2008 International Eurasip Conference (Biosignal Brno, Czech Republic 2008) Brno, Czech Republic


Invited Talks:

Correcting Motion Artifacts of OCT Volume Scans at XXXII International Congress of Ophthalmology in Berlin

OCT Image Processing: Tasks, Challenges and Solutions at Brno University of Technology (DAAD Project "Multimodal Retina Image Analysis") in Brno, Czech Republic

Segmentation of Retinal Layers on High-Resolution OCT Images at Duke University in Durham, NC, USA

Automated Glaucoma Detection with Ophthalmic Imaging Devices at 4th International Workshop on Data - Algorithms - Decision Making 2008) in Loucen, Czeck republic


SAOT provides an interdisciplinary research and education program of excellence within a broad international network of distinguished experts to promote innovation and leadership in the areas

Optical Metrology
Optical Material Processing
Optics in Medicine
Optics in Communication and Information Technology
Optical Materials and Systems
and Computational Optics.