(1)The potential of near-infrared time-resolved spectroscopy as an index of pivotal organs and tissue oxygenation in critically ill patients and (2) Efficacy of Recombinant Human Soluble Thrombomodulin in Disseminated Intravascular Coagulation

Near-infrared spectroscopy (NIRS) is a cerebral monitoring method that noninvasively and continuously measures cerebral hemoglobin oxygenation and the redox state of cytochrome oxidase using highly tissue-permeable near-infrared light. This technique now has wide clinical application, and its usefulness in the measurement of cerebral hemoglobin oxygenation has been confirmed under global cerebral injury and/or hypoxemic hypoxia; however, regional cerebral infarction located far from the monitoring site may not be detected by NIRS. Furthermore, the specificity and accuracy of the measurement of the redox state of cytochrome oxidase remain controversial. We applied NIRS to both animal and clinical investigations. Based on these results, we discuss the significance of the measurement of cerebral hemoglobin oxygenation and cerebral cytochrome oxidase in vivo and in clinical medicine, especially, the effect of the aggressive cerebral management with cytochrome oxidase monitoring on the postoperative neurological outcome.